Mercenene is the name of a substance in the Quahog clam shell that has been researched to have anti-tumor properties. According to Grok on x.com, this is the definition of Mercenene.
Researching Mercenene
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The request is about "Mercenene" and quahog clam anti-tumor properties researched by Schmeer. I'm wondering if "Mercenene" is a typo or a specific term related to quahogs.
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Let's
Searching for "quahog clam anti-tumor properties"
Northern Quahog | NOAA Fisheries
www.fisheries.noaa.gov
Quahog Clam -
gulfspecimen.org
Hard clam - Wikipedia
en.wikipedia.org
A Guide to Clam Types and What to Do With Them
www.seriouseats.com
Quahog Clam | Buy Mercenaria Mercenaria Clams | Gulf Of Maine, Inc.
gulfofme.com
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Quahog clams are hard-shelled, scientifically Mercenaria mercenaria, native to North America's eastern shores, and prized for eating. There's no direct mention of "Mercenene" or anti-tumor properties in general search results.
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A PubMed article discusses anti-tumor activity in polysaccharides from freshwater clam Corbicula fluminea, suggesting clams might have such compounds, but it's not specific to quahogs.
Searching for "quahog clam anti-tumor Schmeer"
Quahog Clam -
gulfspecimen.org
Quahog Clam Animal Facts - Mercenaria mercenaria - A-Z Animals
a-z-animals.com
The Quahog Clam: A Delicious Treat from the Sea - Wild Explained
wildexplained.com
Northern Quahog | NOAA Fisheries
www.fisheries.noaa.gov
De Quahog Clam: een heerlijke traktatie uit de zee - Wild uitgelegd
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The refined search with "quahog clam anti-tumor Schmeer" didn't yield results on a researcher named Schmeer and quahog anti-tumor properties. It mostly showed general info about quahogs, like habitat and parasites, with no specific studies.
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Maybe "Schmeer" is misspelled or a lesser-known researcher, and the study isn't widely referenced. I'm thinking of checking scientific databases for marine biology or pharmacology next.
Searching for "Mercenaria mercenaria anti-tumor"
Mercenene, a tumor inhibitor from Mercenaria: Purification and characterization studies - ScienceDirect
www.sciencedirect.com
Mercenário – Wikipédia, a enciclopédia livre
pt.wikipedia.org
"Mercenene, a tumor inhibitor from mercenaria, purification and charact" by M R. Schmeer, D Horton et al.
mouseion.jax.org
Mercenaria mercenaria (northern quahog)
animaldiversity.org
Mercenari - Viquipèdia, l'enciclopèdia lliure
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Just found a 1966 study by M R. Schmeer, D Horton, and A Tanimura on "Mercenene, a tumor inhibitor from Mercenaria" ScienceDirect. It seems to match the user's query, mentioning "Mercenene" from quahog clams and including Schmeer as an author.
Browsing sciencedirect.com for "Mercenene anti-tumor properties from Mercenaria mercenaria"
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Mercenene is a tumor inhibitor from quahog clams, showing antitumor activity against human HeLa cancer cells in tissue culture ScienceDirect. It's slowly dialyzable and heat stable, published in 1966 with Schmeer as an author.
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The user asked for info based on Schmeer's research, and this study fits perfectly. I'm wondering if there are more details in the full text to share.
Searching for "Mercenene anti-tumor properties recent studies"
Mercenene, a tumor inhibitor from Mercenaria: Purification and characterization studies - ScienceDirect
www.sciencedirect.com
ResearchGate | Find and share research
www.researchgate.net
Mercenene, a tumor inhibitor from mercenaria, purification and characterization studies.
mouseion.jax.org
Mercenene: an antineoplastic agent extracted from the marine clam, Mercenaria mercenaria - PubMed
pubmed.ncbi.nlm.nih.gov
Curcumin: A review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma | Molecular Cancer | Full Text
molecular-cancer.biomedcentral.com
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Recent searches for "Mercenene anti-tumor properties" didn't find new studies. Results mostly point back to the 1966 Schmeer study, with no updates.
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It looks like Mercenene hasn't been researched much lately, or at least, recent findings aren't widely available. I'll stick to the original study for now.
Completed
1. Mercenene, a tumor inhibitor from Mercenaria: Purification and characterization studies - ScienceDirect
vivo antitumor activity, ascribed to the presence of a biologically-active principle named mercenene. In purified preparations mercenene is shown to be slowly dialyzable, heat stable, and highly active in tissue culture against human HeLa cancer cells. Chemical characterization studies on mercenene are described.
sciencedirect.com
2. ResearchGate | Find and share research
researchgate.net
3. Mercenene, a tumor inhibitor from mercenaria, purification and characterization studies.
Mercenene, a tumor inhibitor from mercenaria, purification and characterization studies. M R. Schmeer D Horton A Tanimura ... Life Sci 1966; 5:1169-78.
mouseion.jax.org
4. Mercenene: an antineoplastic agent extracted from the marine clam, Mercenaria mercenaria - PubMed
GROWTH-INHIBITING AGENTS FROM MERCENARIA EXTRACTS: CHEMICAL AND BIOLOGICAL PROPERTIES. SCHMEER MR. SCHMEER MR. Science. 1964 Apr 24;144(3617):413-4. doi: 10.1126/science.144.3617.413. Science. 1964. PMID: 14169329 · An investigation of the anticarcinogenic agent mercenene. 3. The effect of mercenene on the growth of Krebs-2 carcinoma. Fishtein M, Piscitelli J. Fishtein M, et al. J Am Osteopath Assoc. 1971 Jun;70(10):1079-82. J Am Osteopath Assoc. 1971. PMID: 5207156 No abstract available. Purification and characterization of mercenene. I. Ammonium sulfate fractionation and its effect on the growth of Krebs-2 carcinoma. Kolman S, Espenshade L, Zahorian G, Carr M, Nicholas A, Lin YC. Kolman S, et al. J Am Osteopath Assoc. 1972 Oct;72(2):182-4. J Am Osteopath Assoc. 1972. PMID: 4484632 No abstract available. Cucurbitacines, cytotoxic and antitumor substances from Bryonia alba L. Part II: Biological studies.
pubmed.ncbi.nlm.nih.gov
5. Curcumin: A review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma | Molecular Cancer | Full Text
Curcumin (diferuloylmethane) is a polyphenol derived from the Curcuma longa plant, commonly known as turmeric. Curcumin has been used extensively in Ayurvedic medicine for centuries, as it is nontoxic and has a variety of therapeutic properties including anti-oxidant, analgesic, anti-inflammatory and antiseptic activity. More recently curcumin has been found to possess anti-cancer activities via its effect on a variety of biological pathways involved in mutagenesis, oncogene expression, cell cycle regulation, apoptosis, tumorigenesis and metastasis. Curcumin has shown anti-proliferative effect in multiple cancers, and is an inhibitor of the transcription factor NF-κB and downstream gene products (including c-myc, Bcl-2, COX-2, NOS, Cyclin D1, TNF-α, interleukins and MMP-9). In addition, curcumin affects a variety of growth factor receptors and cell adhesion molecules involved in tumor growth, angiogenesis and metastasis.
molecular-cancer.biomedcentral.com
6. Anti-Cancer Potential of Cannabinoids, Terpenes, and Flavonoids Present in Cannabis - PMC
In vivo, 10 and 20 mg/kg of 4-terpineol decreased the tumor weight and tumor volume in a dose-dependent manner [261]. Finally, α-terpineol potentiated the cytotoxic effects induced by oxaliplatin and 5-fluorouracil in a colon cancer cell line [264]. Terpinenes are classified as monoterpenes. α-terpinene can be found in cardamom and marjoram oils and displays an aroma described as woody with hints of pine, citrus and spicy mint. γ-terpinene has been isolated from a variety of plant sources, such as citrus, and displays a woody, lemon-lime scent. δ-terpinene (also known as terpinolene) can also be found in sage, rosemary, apples, tea trees, cumin and nutmeg. It also exudes woodsy aroma with citrus and floral notes. β-terpinene has not been found in a natural source. Studies showed that some essential oils containing γ-terpinene exhibited antiproliferative properties in multiple cell lines, including MCF-7, 4T1, HepG2, Jurkat, and HeLa cancer cells.
ncbi.nlm.nih.gov
7. Mercenene Medical Research Foundation in Cape Vincent, New York (NY) - NonProfitFacts.com
nonprofitfacts.com
8. Cannabinoids as anticancer drugs: current status of preclinical research | British Journal of Cancer
Drugs that target the endocannabinoid system are of interest as pharmacological options to combat cancer and to improve the life quality of cancer patients. From this perspective, cannabinoid compounds have been successfully tested as a systemic therapeutic option in a number of preclinical models over the past decades. As a result of these efforts, a large body of data suggests that the anticancer effects of cannabinoids are exerted at multiple levels of tumour progression via different signal transduction mechanisms. Accordingly, there is considerable evidence for cannabinoid-mediated inhibition of tumour cell proliferation, tumour invasion and metastasis, angiogenesis and chemoresistance, as well as induction of apoptosis and autophagy. Further studies showed that cannabinoids could be potential combination partners for established chemotherapeutic agents or other therapeutic interventions in cancer treatment.
nature.com
9. Systematic literature review of efficacy, safety and tolerability outcomes of chemotherapy regimens in patients with metastatic Merkel cell carcinoma ...
In an ongoing, multicenter, Phase II trial of 88 patients with MCC (largest MCC trial to date), treatment with avelumab, an investigational anti-PD-L1 therapy, showed durable antitumor activity in patients with chemotherapy-refractory metastatic MCC in second- and further-line therapy. In this trial, the ORR was 32%; 23/28 responses (82%) were ongoing at the time of the report; the 6-month DoR was 29%; the 6-month PFS rate was 40%; and the 6-month OS rate was 69%. Responses to avelumab occurred in patients with PD-L1+ and PD-L1- tumors, and MCPyV+ and MCPyV- tumors [95]. Similarly, in another ongoing, multicenter, Phase II noncontrolled study in patients with previously untreated (first-line), advanced (locoregional or distant) MCC, pembrolizumab was associated with an ORR of 56% [96], with responses in patients with McPyV+ and McPyV- tumors (ORRs of 62 and 44%, respectively).
pmc.ncbi.nlm.nih.gov
10. Bioactive Compounds: Natural Defense Against Cancer? - PMC
Cancer is a devastating disease that has claimed many lives. Natural bioactive agents from plants are gaining wide attention for their anticancer activities. Several studies have found that natural plant-based bioactive compounds can enhance the efficacy of chemotherapy, and in some cases ameliorate some of the side-effects of drugs used as chemotherapeutic agents. In this paper, we have reviewed the literature on the anticancer effects of four plant-based bioactive compounds namely, curcumin, myricetin, geraniin and tocotrienols (T3) to provide an overview on some of the key findings that are related to this effect. The molecular mechanisms through which the active compounds may exert their anticancer properties in cell and animal-based studies also discussed. Keywords: bioactive compounds, anticancer, curcumin, myricetin, geraniin, tocotrienols ·
pmc.ncbi.nlm.nih.gov
